Your dream job finally appears after much prayer and effort on your part. Things are going well; you're learning new things, and you have a great rapport with your coworkers. You start to breathe. You've made it past the first year, but now there are rumors of layoffs. Typically you'd ignore these but see your coworkers falling left and right. Then one day, it's your turn.
Or you've just moved and met the friend you hoped for. You've spent significant time in prayer about this friendship. Things go smoothly until you hit a road bump - this relationship looks pretty one-sided. You're unable to salvage the relationship, so now you're friendless (again).